|
Iron overload, also known as hemochromatosis or haemochromatosis, indicates accumulation of iron in the body from any cause. The most important causes are hereditary haemochromatosis (HHC), a genetic disorder, and transfusional iron overload, which can result from repeated blood transfusions.〔 ==Signs and symptoms== Organs commonly affected by haemochromatosis are the liver, heart, and endocrine glands. Haemochromatosis may present with the following clinical syndromes: * Cirrhosis of the liver: Varies from zonal iron deposition〔Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol Int. 1995 Mar;45(3):202-6. PubMed PMID 7787990.〕 to fibrosis (cirrhosis). * Diabetes due to selective iron deposition in pancreatic islet beta cells leading to functional failure and cell death.〔Lu JP, Hayashi K. Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases. Pathol Int. 1994 Mar;44(3):194-9. PubMed PMID 8025661.〕〔Lu JP, Hayashi K. Transferrin receptor distribution and iron deposition in the hepatic lobule of iron-overloaded rats. Pathol Int. 1995 Mar;45(3):202-6. PubMed PMID 7787990.〕 * Cardiomyopathy * Arthritis (calcium pyrophosphate deposition in joints) * Testicular failure * Slate grey discoloration of the skin * Joint pain and bone pain〔http://www.mayoclinic.com/health/hemochromatosis/DS00455/DSECTION=symptoms〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「iron overload」の詳細全文を読む スポンサード リンク
|